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Пробіотик Bifidobacterium animalis subsp. lactis BB-12™: в чому його користь та як він впливає на організм людини

Пробіотик Bifidobacterium animalis subsp. lactis BB-12™: в чому його користь та як він впливає на організм людини

ТМ «Яготинське» запустила лінійку біфідойогуртів  без наповнювачів, які містять пробіотичні культури Bifidobacterium animalis subsp. lactis BB-12™.

  • Торгова марка з насиченою історією якості тривалістю понад півстоліття

ТМ «Яготинське» випустила біфідойогурт без наповнювача, який містить в пляшці 270 грамів та в плівці 400 грамів більше мільярда пробіотичних культур Bifidobacterium animalis subsp. lactis BB-12™. Біфідойогурт має позитивний вплив на здоров’я в цілому та на функції шлунково-кишкового тракту зокрема.

Для початку, давайте розберемося, що таке пробіотики. Пробіотики — це живі мікроорганізми, які можуть позитивно впливати на здоров'я людини та нормалізувати склад і функції мікрофлори шлунково-кишкового тракту. Найчастіше це біфідобактерії і лактобацили, які здатні проявляти антагонізм проти патогенних й умовно-патогенних мікробів.

Пробіотик Bifidobacterium animalis subsp. lactis BB-12™ є найбільш дослідженим (задокументованим) пробіотичним штамом Bifidobacterium. Його корисний вплив було доведено численними дослідженнями, опублікованими на авторитетному ресурсі PubMed. Ознайомитися з дослідженнями ви можете за посиланнями нижче:

Volokh O, Klimenko N, Berezhnaya Y, et al. Human Gut Microbiome Response Induced by Fermented Dairy Product Intake in Healthy Volunteers. Nutrients. 2019;11(3):547. Published 2019 Mar 4. doi:10.3390/nu11030547

https://pubmed.ncbi.nlm.nih.gov/30836671/

Nocerino R, De Filippis F, Cecere G, et al. The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12® in infant colic: A randomised, double blind, placebo-controlled trial. Aliment Pharmacol Ther. 2020;51(1):110-120. doi:10.1111/apt.15561

https://pubmed.ncbi.nlm.nih.gov/31797399/

Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014;2(2):92-110. Published 2014 Mar 28. doi:10.3390/microorganisms2020092

https://pubmed.ncbi.nlm.nih.gov/27682233/

Tan TP, Ba Z, Sanders ME, et al. Safety of Bifidobacterium animalis Subsp. Lactis (B. lactis) Strain BB-12-Supplemented Yogurt in Healthy Children. J Pediatr Gastroenterol Nutr. 2017;64(2):302-309. doi:10.1097/MPG.0000000000001272

https://pubmed.ncbi.nlm.nih.gov/28114246/

Ashraf R, Shah NP. Immune system stimulation by probiotic microorganisms. Crit Rev Food Sci Nutr. 2014;54(7):938-956. doi:10.1080/10408398.2011.619671

https://pubmed.ncbi.nlm.nih.gov/24499072/

Reuter G. The Lactobacillus and Bifidobacterium microflora of the human intestine: composition and succession. Curr Issues Intest Microbiol. 2001 Sep;2(2):43-53. PMID: 11721280. - PubMed

Garrigues C., Stuer-Lauridsen B., Johansen E. Characterisation of Bifidobacterium animalis subsp. lactis BB-12 and other probiotic bacteria using genomics, transcriptomics and proteomics. Aust. J. Dairy Technol. 2005; 60: 84-92.

Garrigues C, Johansen E, Pedersen MB. Complete genome sequence of Bifidobacterium animalis subsp. lactis BB-12, a widely consumed probiotic strain. J Bacteriol. 2010 May;192(9):2467-8. doi: 10.1128/JB.00109-10. Epub 2010 Feb 26. PMID: 20190051; PMCID: PMC2863482. - DOI - PMC - PubMed

Pedersen MB, Iversen SL, Sørensen KI, Johansen E. The long and winding road from the research laboratory to industrial applications of lactic acid bacteria. FEMS Microbiol Rev. 2005 Aug;29(3):611-24. doi: 10.1016/j.femsre.2005.04.001. PMID: 15935510. - DOI - PubMed

Garrigues C, Johansen E, Crittenden R. Pangenomics--an avenue to improved industrial starter cultures and probiotics. Curr Opin Biotechnol. 2013 Apr;24(2):187-91. doi: 10.1016/j.copbio.2012.08.009. Epub 2012 Sep 10. PMID: 22975152. - DOI - PubMed

Vernazza CL, Gibson GR, Rastall RA. Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacterium. J Appl Microbiol. 2006 Apr;100(4):846-53. doi: 10.1111/j.1365-2672.2006.02832.x. PMID: 16553741. - DOI - PubMed

Matsumoto M, Ohishi H, Benno Y. H+-ATPase activity in Bifidobacterium with special reference to acid tolerance. Int J Food Microbiol. 2004 May 15;93(1):109-13. doi: 10.1016/j.ijfoodmicro.2003.10.009. PMID: 15135587. - DOI - PubMed

C.G. Vinderola, J.A. Reinheimer, Lactic acid starter and probiotic bacteria: a comparative “in vitro” study of probiotic characteristics and biological barrier resistance. Food Res. Int. 2003; 36: 895-904. doi: 10.1016 / S0963-9969 (03) 00098-X. - DOI

Laparra JM, Sanz Y. Comparison of in vitro models to study bacterial adhesion to the intestinal epithelium. Lett Appl Microbiol. 2009 Dec;49(6):695-701. doi: 10.1111/j.1472-765X.2009.02729.x. Epub 2009 Aug 25. PMID: 19843211. - DOI - PubMed

Rinkinen M, Westermarck E, Salminen S, Ouwehand AC. Absence of host specificity for in vitro adhesion of probiotic lactic acid bacteria to intestinal mucus. Vet Microbiol. 2003 Dec 2;97(1-2):55-61. doi: 10.1016/s0378-1135(03)00183-4. PMID: 14637038. - DOI - PubMed

He F, Ouwehan AC, Hashimoto H, Isolauri E, Benno Y, Salminen S. Adhesion of Bifidobacterium spp. to human intestinal mucus. Microbiol Immunol. 2001;45(3):259-62. doi: 10.1111/j.1348-0421.2001.tb02615.x. PMID: 11345536. - DOI - PubMed

Juntunen M, Kirjavainen PV, Ouwehand AC, Salminen SJ, Isolauri E. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol. 2001 Mar;8(2):293-6. doi: 10.1128/CDLI.8.2.293-296.2001. PMID: 11238211; PMCID: PMC96052. - PMC - PubMed

Martins FS, Silva AA, Vieira AT, Barbosa FH, Arantes RM, Teixeira MM, Nicoli JR. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol. 2009 Aug;191(8):623-30. doi: 10.1007/s00203-009-0491-x. Epub 2009 Jun 13. PMID: 19526225. - DOI - PubMed

Collado MC, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol. 2007 Oct;45(4):454-60. doi: 10.1111/j.1472-765X.2007.02212.x. PMID: 17897389. - DOI - PubMed

Collado MC, Grzeskowiak L., Salminen S. Probiotic strains and their combination inhibit in vitro adhesion of pathogens to pig intestinal mucosa. Тек. Microbiol. 2007; 55: 260-265. doi: 10.1007 / s00284-007-0144-8. - DOI - PubMed

Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM, Rowland IR. Effects of fermentation products of pro- and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer. 2005;51(1):102-9. doi: 10.1207/s15327914nc5101_14. PMID: 15749636. - DOI - PubMed

López P, Gueimonde M, Margolles A, Suárez A. Distinct Bifidobacterium strains drive different immune responses in vitro. Int J Food Microbiol. 2010 Mar 31;138(1-2):157-65. doi: 10.1016/j.ijfoodmicro.2009.12.023. Epub 2010 Jan 4. PMID: 20071048. - DOI - PubMed

Latvala S, Pietila TE, Veckman V, Kekkonen RA, Tynkkynen S, Korpela R, Julkunen I. Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells. World J Gastroenterol. 2008 Sep 28;14(36):5570-83; discussion 5581-2. doi: 10.3748/wjg.14.5570. PMID: 18810777; PMCID: PMC2746346. - DOI - PMC - PubMed

Matsumoto M, Hara K, Benno Y. The influence of the immunostimulation by bacterial cell components derived from altered large intestinal microbiota on probiotic anti-inflammatory benefits. FEMS Immunol Med Microbiol. 2007 Apr;49(3):387-90. doi: 10.1111/j.1574-695X.2007.00215.x. PMID: 17378901. - DOI - PubMed

Black, F. T. (1996). Placebo-controlled double-blind investigation of 4 Lactobacillus strains (HIP) used as prophylactic agent against traveller's diarrhea (2 trials). Report to G. Niernberger, Bioconsult; Vienna, Austria.

Palaria A, Johnson-Kanda I, O'Sullivan DJ. Effect of a synbiotic yogurt on levels of fecal bifidobacteria, clostridia, and enterobacteria. Appl Environ Microbiol. 2012 Feb;78(4):933-40. doi: 10.1128/AEM.05848-11. Epub 2011 Nov 18. PMID: 22101054; PMCID: PMC3272998. - DOI - PMC - PubMed

Larsen CN, Nielsen S, Kaestel P, Brockmann E, Bennedsen M, Christensen HR, Eskesen DC, Jacobsen BL, Michaelsen KF. Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults. Eur J Clin Nutr. 2006 Nov;60(11):1284-93. doi: 10.1038/sj.ejcn.1602450. Epub 2006 May 24. PMID: 16721394. - DOI - PubMed

Jaana Mättö, Rangne Fondén, Tiina Tolvanen, Atte von Wright, Terttu Vilpponen-Salmela, Reetta Satokari, Maria Saarela, Intestinal survival and persistence of probiotic Lactobacillus and Bifidobacterium strains administered in triple-strain yoghurt. Int. Dairy J. 2006; 16: 1174–1180. doi: 10.1016 / j.idairyj.2005.10.007. - DOI

M. Alander, J. Mättö, W. Kneifel, M. Johansson, B. Kögler, R. Crittenden, T. Mattila-Sandholm, M. Saarela, Effect of galacto-oligosaccharide supplementation on human faecal microflora and on survival and persistence of Bifidobacterium lactis Bb-12 in the gastrointestinal tract. Int. Dairy J. 2001; 11: 817-825. doi: 10.1016 / S0958-6946 (01) 00100-5. - DOI

Savard P, Lamarche B, Paradis ME, Thiboutot H, Laurin É, Roy D. Impact of Bifidobacterium animalis subsp. lactis BB-12 and, Lactobacillus acidophilus LA-5-containing yoghurt, on fecal bacterial counts of healthy adults. Int J Food Microbiol. 2011 Sep 1;149(1):50-7. doi: 10.1016/j.ijfoodmicro.2010.12.026. Epub 2011 Jan 15. PMID: 21296446. - DOI - PubMed

Pitkala KH, Strandberg TE, Finne Soveri UH, Ouwehand AC, Poussa T, Salminen S. Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial. J Nutr Health Aging. 2007 Jul-Aug;11(4):305-11. PMID: 17653486. - PubMed

Uchida K., Akashi K., Kusunoki I., Ikeda T., Katano N., Motoshima H., Benno Y. Effect of fermented milk containing Bifidobacterium lactis BB-12® on stool frequency, defecation, fecal microbiota and safety of excessive ingestion in healthy female students. J. Nutr. Food. 2005; 8: 39-51.

Nishida S., Goto M., Akutsu S., Ono M., Hitomi Y., Nakamura T., Iino H. Effect of yogurt containing Bifidobacterium lactis BB-12 on the improvement of defecation and fecal microflora in healthy female adults. Milk Sci. 2004; 53: 71-80.

Matsumoto M., Imai T., Hironaka T., Kume H., Watanabe M., Benno Y. Effect of yogurt with Bifidobacterium lactis LKM512 on the improvement of fecal microflora and defecation in healthy volunteers. Intest. Microbiol. Mag. 2001; 14: 97-102.

Chouraqui JP, Van Egroo LD, Fichot MC. Acidified milk formula supplemented with bifidobacterium lactis: impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr. 2004 Mar;38(3):288-92. doi: 10.1097/00005176-200403000-00011. PMID: 15076628.. - DOI - PubMed

Saavedra JM, Bauman NA, Oung I, Perman JA, Yolken RH. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet. 1994 Oct 15;344(8929):1046-9. doi: 10.1016/s0140-6736(94)91708-6. PMID: 7934445. - DOI - PubMed

Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated diarrhoea. J Assoc Physicians India. 2013 Oct;61(10):708-12. PMID: 24772726. - PubMed

de Vrese M, Kristen H, Rautenberg P, Laue C, Schrezenmeir J. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity. J Dairy Res. 2011 Nov;78(4):396-403. doi: 10.1017/S002202991100063X. Epub 2011 Aug 26. PMID: 21871144. - DOI - PubMed

Sheu BS, Wu JJ, Lo CY, Wu HW, Chen JH, Lin YS, Lin MD. Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment. Pharmacol. Ther. 2002; 16: 1669-1675. doi: 10.1046 / j.1365-2036.2002.01335.x. - DOI - PubMed

Wang KY, Li SN, Liu CS, Perng DS, Su YC, Wu DC, Jan CM, Lai CH, Wang TN, Wang WM. Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori. Am. J. Clin. Nutr. 2004; 80: 737-741. - PubMed

Sheu BS, Cheng HC, Kao AW, Wang ST, Yang YJ, Yang HB, Wu JJ. Pretreatment with Lactobacillus- and Bifidobacterium-containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am. J. Clin. Nutr. 2006; 83: 864-869. - PubMed

Albers R., Antoine JM, Bourdet-Sicard R., Calder PC, Gleeson M., Lesourd B., Samartin S., Sanderson IR, van Loo J., Vas Dias FW, et al. Markers to measure immunomodulation in human nutrition intervention studies. Br. J. Nutr. 2005; 94: 452-481. doi: 10.1079 / BJN20051469. - DOI - PubMed

Burleson GR, Burleson FG. Influenza virus host resistance model. 2007; 41: 31-37. doi: 10.1016 / j.ymeth.2006.09.007. - DOI - PubMed

Rizzardini G., Eskesen D., Calder PC, Capetti A., Jespersen L., Clerici M. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study. Br. J. Nutr. 2012; 107: 876-884. doi: 10.1017 / S000711451100420X. - DOI - PubMed

Smith TJ, Rigassio-Radler D., Denmark R., Haley T., Touger-Decker R. Effect of Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on health-related quality of life in college students affected by upper respiratory infections. Br. J. Nutr. 2013; 109: 1999-2007. doi: 10.1017 / S0007114512004138. - DOI - PubMed

Taipale T., Pienihakkinen K., Isolauri E., Larsen C., Brockmann E., Alanen P., Jokela J., Soderling E. Bifidobacterium animalis subsp. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br. J. Nutr. 2011; 105: 409-416. doi: 10.1017 / S0007114510003685. - DOI - PubMed

Rautava S, Salminen S, Isolauri E. Specific probiotics in reducing the risk of acute infections in infancy — a randomised, double-blind, placebo-controlled study. Br J Nutr. 2009 Jun;101(11):1722-6. doi: 10.1017/S0007114508116282. Epub 2008 Nov 6. PMID: 18986600. - DOI - PubMed

  • Торгова марка з насиченою історією якості тривалістю понад півстоліття